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Article
February 1988

Leuko-Araiosis: The Brain Interstitial Atrophy (Atrophie Interstitielle du Cerveau) of Durand-Fardel

Author Affiliations

Laboratoire Raymond Escourolle Hôpital de La Salpètrière, 47 Blvd de l'Hôpital, F 75651 Paris Cedex 13, France

Arch Neurol. 1988;45(2):140. doi:10.1001/archneur.1988.00520260026011
Abstract

To the Editor.  —In the excellent article by Hachinski et al,1 emphasis is placed on deep white-matter changes often seen in elderly patients on computed tomographic (CT) scans, which can be "associated with intellectual impairment and somewhat, but not exclusively, with vascular disease." The authors suggest the term leukoaraiosis, meaning "a diminution of the density of representation of the white matter," without implying a specific pathologic change. It may be pointed out that Durand-Fardel fully described, in 1854, on macroscopic examination of the brain, "l'atrophie interstitielle du cerveau" ("brain interstitial atrophy").2 He described this hitherto unrecognized change of brain tissue as follows: "Cette atrophie interstitielle se montre dans la substance blanche et dans la substance grise, plus souvent dans la première, tantôt sous forme de points circonscrits isolés ou répandus par tout le cerveau, tantôt sous forme de noyaux occupant une certaine étendue d'un hémisphère. Dans ce dernier

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