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March 1988

Tropical Spastic Paraparesis: Lack of Human T-Lymphotropic Virus Type I Antibodies in Blood Donors From Bogota, Colombia

Author Affiliations

Texas Tech University Health Sciences Center School of Medicine Lubbock, TX 79430
National Institute of Neurological and Communicative Disorders and Stroke Bethesda, MD 20892
San Juan de Dios University Hospital National University of Colombia Bogotá, Colombia

Arch Neurol. 1988;45(3):244-245. doi:10.1001/archneur.1988.00520270014008

To the Editor.  —Recent reports1,2 indicate the presence of positive human T-lymphotropic virus type I (HTLV-I) antibodies in the cerebrospinal fluid of 16 (73% ) of 22 subjects, and in 94% of the serum samples of Colombian patients with tropical spastic paraparesis (TSP). In a previous neuroepidemiologic study,3 we have shown clustering of TSP cases in the southern Pacific lowlands in Colombia, mainly around the port town of Tuma co. However, there are no prevalence studies of HTLV-I or adult T-cell leukemia and non-Hodgkin's lymphoma from Colombia. For this reason, we studied serum samples from blood donors at the San Juan de Dios University Hospital in Bogotá.

Materials and Methods.  —Serum samples from 145 adult blood donors were frozen and transported in dry ice to the Immunochemistry and Clinical Investigations Section, Infectious Disease Branch, National Institute of Neurological Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md. Serum

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