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June 1988

Anticardiolipin Antibodies and Migraine-Related Strokes

Author Affiliations

Neurology Service Department of Internal Medicine Vall D'Hebrón Hospital c/Girona, 8 08915-Badalona Barcelona, Spain

Arch Neurol. 1988;45(6):603. doi:10.1001/archneur.1988.00520300017008

To the Editor.   —We read the excellent review by Levine and Welch1 on neurologic disease associated with antiphospholipid antibodies with interest. They suggest more than a chance association between antiphospholipid antibodies and migraine. We have studied the incidence of IgM and IgG anticardiolipin antibodies (ACAs) in an enzyme-linked immunosorbent solid-phase assay in 18 patients with migraine-related strokes. The following criteria had to be met for inclusion in the study: (1) there was a clear history of migraine attacks preceding or following the stroke; (2) a neurologic deficit occurred in conjunction with headache; (3) the patient's neurologic deficit must have lasted longer than 24 hours; (4) evidence of an ischemic infarct as demonstrated by computed tomographic findings or magnetic resonance imaging; and (5) no other mechanism of brain infarction was evident from the history, examination results, or available laboratory data. Twelve patients were female. Age at the time of

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