To the Editor.
—We read the excellent review by Levine and Welch1 on neurologic disease associated with antiphospholipid antibodies with interest. They suggest more than a chance association between antiphospholipid antibodies and migraine. We have studied the incidence of IgM and IgG anticardiolipin antibodies (ACAs) in an enzyme-linked immunosorbent solid-phase assay in 18 patients with migraine-related strokes. The following criteria had to be met for inclusion in the study: (1) there was a clear history of migraine attacks preceding or following the stroke; (2) a neurologic deficit occurred in conjunction with headache; (3) the patient's neurologic deficit must have lasted longer than 24 hours; (4) evidence of an ischemic infarct as demonstrated by computed tomographic findings or magnetic resonance imaging; and (5) no other mechanism of brain infarction was evident from the history, examination results, or available laboratory data. Twelve patients were female. Age at the time of
Montalban J, Titus F, Ordi J, Barquinero J. Anticardiolipin Antibodies and Migraine-Related Strokes. Arch Neurol. 1988;45(6):603. doi:10.1001/archneur.1988.00520300017008
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