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June 1988

Multiple Sclerosis, Solvents, and Pets: A Case-Referent Study

Author Affiliations

From the Departments of Occupational Medicine (Drs Flodin and Axelson, Ms Noorlind-Brage, and Mr Fredriksson) and Neurology (Dr Söderfeldt), University Hospital, Linköping, Sweden.

Arch Neurol. 1988;45(6):620-623. doi:10.1001/archneur.1988.00520300038015

• The effect of potential risk factors for multiple sclerosis was evaluated in a case-referent study that encompassed 83 cases and 467 randomized referents. Information on exposure was obtained by questionnaires that were mailed to the subjects. Mantel-Haenszel rate ratios were increased for males for occupational exposure to solvents and welding and for females for leisure time contact with dogs and caged birds. For both sexes, x-ray film examination occurred more frequently among cases than referents, possibly as an effect of early symptoms from the disease itself.

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