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June 1988

A Direct Electron Microscopic Immunocytochemical Study of IgM Paraproteinemic Neuropathy

Author Affiliations

From the Department of Neurology, Veterans Administration Medical Center and University of Michigan, Ann Arbor (Drs Mata and Fink), and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia (Dr Kahn). Dr Kahn is currently with the; Department of Pathology, St Luke's Hospital, Bethlehem, Pa.

Arch Neurol. 1988;45(6):693-697. doi:10.1001/archneur.1988.00520300113031

• Direct electron microscopic immunohistochemistry of the sural nerve of a patient with neuropathy and an IgMk paraprotein demonstrated that immunoglobulin was deposited throughout the compact myelin. These findings support the notion that immunoglobulin deposition plays a role in the pathogenesis of the neuropathy in vivo.

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