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Article
July 1988

Reductions in Acetylcholine and Nicotine Binding in Several Degenerative Diseases

Author Affiliations

From the Neuropathology Laboratory (Drs Whitehouse, Zweig, and Price and Ms Marcus), the Departments of Neurology (Drs Whitehouse, Singer, and Price), Neuroscience (Drs Whitehouse and Price), Pathology (Drs Zweig and Price), and Pediatrics (Dr Singer), The Johns Hopkins University School of Medicine, Baltimore; Department of Pharmacology (Dr Kellar and Ms Martino), Georgetown University School of Medicine and Dentistry, Washington, DC; and Alzheimer Center, University Hospitals of Cleveland (Dr Whitehouse).

Arch Neurol. 1988;45(7):722-724. doi:10.1001/archneur.1988.00520310028012
Abstract

• Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.

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