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July 1988

Differential Mood Changes Following Basal Ganglia vs Thalamic Lesions

Author Affiliations

From the Departments of Psychiatry and Behavioral Sciences (Drs Starkstein, Robinson, and Parikh) and Neurosciences (Dr Robinson), The Johns Hopkins University School of Medicine and the Department of Neurology, University of Maryland School of Medicine (Dr Price), Baltimore; and the Raul Carrea Institute of Neurological Research, Buenos Aires (Dr Berthier).

Arch Neurol. 1988;45(7):725-730. doi:10.1001/archneur.1988.00520310031013

• Patients with computed tomographic scan-verified unilateral lesions in the basal ganglia or thalamus were examined for the presence of poststroke mood disorders. Patients with left-sided basal ganglia lesions (mainly in the head of the caudate nucleus) showed a significantly higher frequency and severity of depression, as compared with patients with right-sided basal ganglia or thalamic (leftor right-sided) lesions. Results suggest that damage to biogenic amine pathways and/or frontocaudate projections may play an important role in the modulation of mood.

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