• Acute encephalopathy and an abnormal electroencephalogram with a periodic sharp wave pattern developed in a 58-year-old woman shortly after she received a few doses of baclofen. The clinical and electroencephalographic abnormalities improved promptly after the medication was discontinued.
Hormes JT, Benarroch EE, Rodriguez M, Klass DW. Periodic Sharp Waves in Baclofen-Induced Encephalopathy. Arch Neurol. 1988;45(7):814–815. doi:10.1001/archneur.1988.00520310132033