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August 1988

Studies of Transketolase Abnormality in Alzheimer's Disease

Author Affiliations

From the Departments of Neurology (Drs Sheu, Clarke, and Blass and Mr Harding and Mr DeCicco) and Medicine (Drs Kim and Blass), Cornell University Medical College, New York, and the Dementia Research Service, Burke Rehabilitation Center, White Plains, NY (Drs Sheu, Clarke, and Blass and Mr Harding and Mr DeCicco). Dr Clarke is currently with the Department of Chemistry, Fordham University, Bronx, NY.

Arch Neurol. 1988;45(8):841-845. doi:10.1001/archneur.1988.00520320027010

• The partially purified transketolase from each of eight well-nourished patients with Alzheimer's disease contained significantly less heat-stable component with a significantly longer half-life of heat inactivation than that from eight controls. Immunochemical studies utilizing antibodies to the purified human liver transketolase did not distinguish between red blood cell transketolases of patients with Alzheimer's disease and those of controls. However, three brains from patients with Alzheimer's disease that were deficient in transketolase activity lacked a 69-kilodalton form on immunoblots. Subtle structural abnormalities of transketolase appear to occur in a high proportion of patients with Alzheimer's disease.

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