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December 1988

Fulminant Subacute Sclerosing Panencephalitis in Association With Pregnancy

Author Affiliations

From the Department of Neurology, Hadassah University Hospital and Hebrew University Hadassah Medical School, Jerusalem (Drs Wirguin, Steiner, Kidron, Brenner, and Abramsky); the Department of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY (Dr Udem); and the Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beersheva, Israel (Dr Rager).

Arch Neurol. 1988;45(12):1324-1325. doi:10.1001/archneur.1988.00520360042009

• Subacute sclerosing panencephalitis developed during pregnancy in a 27-year-old woman and immediately after delivery in an 18-year-old woman. In both, disease took an acute and fulminant course culminating in a vegetative state within several weeks. It is suggested that the relative older age of disease presentation and the unusually rapid neurologic deterioration were partially due to immunologic and hormonal alterations of pregnancy.

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