—Just prior to the publication of our article1 describing experience with evoked potentials in a clinical treatment trial in multiple sclerosis, Nuwer et al2 detailed their observations in another treatment trial. There is something to be learned by comparing the two. It is important at the onset, however, to understand that there were important differences between the two studies and in their results. On trial in the earlier study was the effectiveness of immunosuppressant therapies in retarding gradual deterioration in patients with chronic progressive multiple sclerosis. The study was planned over the long term so that the effects of slowing the immunopathologic process could be detected. Finally, the study demonstrated significant benefit of the program, both on clinical and electrophysiologic bases.Our study, on the other hand, sought to corroborate earlier observations about short-term improvement related to hyperbaric oxygen treatment.1 The protocol was planned to examine both
Anderson DC, Sherman R. Evoked Potentials During Multiple Sclerosis Therapeutic Trials-Reply. Arch Neurol. 1989;46(1):12–13. doi:10.1001/archneur.1989.00520370014006
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