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Article
January 1989

A Community-Based Study of Parental Age at the Birth of Patients With Dementia of the Alzheimer Type

Author Affiliations
From the Division of Neurology, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan.
Arch Neurol. 1989;46(1):38-39. doi:10.1001/archneur.1989.00520370040016
Abstract

• The association of dementia of the Alzheimer type (DAT) with parental age at the birth of patients who develop DAT was investigated in a community-based study in Japan. Both maternal and paternal ages of patients who have developed DAT are significantly higher than those in controls and multi-infarct dementia. This study suggests that advanced age may become a cause of chromosome abnormality, and advanced parental age at subjects' birth may be a possible risk factor in DAT.

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