• The association of dementia of the Alzheimer type (DAT) with parental age at the birth of patients who develop DAT was investigated in a community-based study in Japan. Both maternal and paternal ages of patients who have developed DAT are significantly higher than those in controls and multi-infarct dementia. This study suggests that advanced age may become a cause of chromosome abnormality, and advanced parental age at subjects' birth may be a possible risk factor in DAT.
Urakami K, Adachi Y, Takahashi K. A Community-Based Study of Parental Age at the Birth of Patients With Dementia of the Alzheimer Type. Arch Neurol. 1989;46(1):38–39. doi:10.1001/archneur.1989.00520370040016