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January 1989

A Community-Based Study of Parental Age at the Birth of Patients With Dementia of the Alzheimer Type

Arch Neurol. 1989;46(1):38-39. doi:10.1001/archneur.1989.00520370040016

• The association of dementia of the Alzheimer type (DAT) with parental age at the birth of patients who develop DAT was investigated in a community-based study in Japan. Both maternal and paternal ages of patients who have developed DAT are significantly higher than those in controls and multi-infarct dementia. This study suggests that advanced age may become a cause of chromosome abnormality, and advanced parental age at subjects' birth may be a possible risk factor in DAT.