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February 1989

Aging and Alzheimer's Disease: Altered Cortical Serotonergic Binding

Author Affiliations

From the Sanders-Brown Research Center on Aging, the Department of Neurology, University of Kentucky Medical Center, and the Kentucky State Medical Examiners Program, Justice Cabinet, Lexington.

Arch Neurol. 1989;46(2):138-140. doi:10.1001/archneur.1989.00520380038010

• The binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with Alzheimer's disease (AD). Using the dopamine-specific receptor antagonist sulpiride, spiperone binding in the cortex was shown to be essentially serotonergic. A decline in both serotonin and spiperone binding was found in normal aging, and an AD-related decrease was found for spiperone binding only. The AD-related decrement of spiperone binding occurred irrespective of patient age and duration of disease. Scatchard analysis indicates that both age- and diseaserelated decrements represent a decrease in receptor number.