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March 1989

Human Immunodeficiency Virus Type 1 Antigen in Cerebrospinal Fluid: Correlation With Clinical Neurologic Status

Author Affiliations

From the Departments of Neurology (Drs Portegies and de Gans) and Virology (Drs Portegies, Epstein, and Goudsmit and Mr Hung), Academic Medical Center, University of Amsterdam; and the Departments of Neurosciences and Pediatrics (Dr Epstein), New Jersey College of Medicine and Dentistry, Newark.

Arch Neurol. 1989;46(3):261-264. doi:10.1001/archneur.1989.00520390027010

• Human immunodeficiency virus type1 (HIV-1) antigen was assayed in paired serum/cerebrospinal fluid (CSF) specimen from 85 adults and 58 children with acquired immunodeficiency syndrome and was compared with clinical neurological status. A quantitative comparison of HIV-1 antigen levels in matched serum and CSF specimens indicated that HIV-1 antigen expression in these compartments is independent and is correlated with acquired immunodeficiency syndrome dementia complex in adults and progressive encephalopathy in children. In a longitudinal study (n = 47), 16 patients tested positive for HIV-1 antigen in the CSF before (n = 2) or coincident (n = 14) with neurological deterioration. Six patients who tested positive for HIV-1 antigen in the CSF remained neurologically normal for a median duration of follow-up of 11 months. Six of 25 patients who tested negative for HIV-1 antigen in the CSF, subsequently showed neurological deterioration. These data indicate that HIV-1 antigen expression in the CSF is not useful in predicting neurological deterioration.

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