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April 1989

Does Neuroretinitis Rule Out Multiple Sclerosis?

Author Affiliations

850 E. Harvard Ave Suite 535 Denver, CO 80210

Arch Neurol. 1989;46(4):358. doi:10.1001/archneur.1989.00520400012003

To the Editor.  —We are writing regarding the article by Parmley et al1 that appeared in the October 1987 issue of the Archives.While we do not question the possibility of neuroretinitis being a separate entity from multiple sclerosis (MS), we believe that the statement "Patients... with a macular star do not have the same chance of MS developing as do patients who have optic neuritis without a star" may overstate the case. The reasons follow.First, the follow-up period for the 10 prospective patients is short, 1 to 2 years.2 Even though the study by Cohen and Lessell3 notes that approximately 40% of patients who would develop definite MS over the 7.1 years of the study did so in the first year (and about 50% in the first 2 years), we now know from their later data4 that, after 15 years, about 80% to 90%

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