To the Editor.
—In a recent article in the Archives, Renard Andersen et al1 reported the results obtained with xenon 133 inhalation in combination with single photon emission computed tomography in classic migraine. The technique permits the detailed examination of cerebral blood flow without actual invasion by puncture or catheterization of the very arteries involved in the examination. It is of great interest to learn that in seven of their 12 patients with classic migraine during seven attacks, even at intervals of 11/2 hours or longer after the onset of the neurologic symptoms, they found major decreases in regional cerebral blood flow in areas corresponding to the clinical symptoms. The degree of hypoperfusion, at some points dipping into the region of actual ischemia, and the subsequent delayed cerebral hyperperfusion in the same location as the areas of hypoperfusion, lead them to the conclusion that "a state of arteriolar vasoconstriction
Spierings ELH, Graham JR. Cerebral Hypoperfusion Followed by Hyperperfusion in Classic Migraine. Arch Neurol. 1989;46(6):605–606. doi:10.1001/archneur.1989.00520420023014
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