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June 1989

Prediction of Language and Neurologic Recovery After Cerebral Infarction With SPECT Imaging Using N-Isopropyl-p-(I 123) Iodoamphetamine

Author Affiliations

From the Nuclear Medicine (Drs Bushnell and Barnes), Neurology (Dr Gupta), and Audiology and Speech Pathology (Dr Mlcoch) Services, Hines (Ill) Veterans Administration Hospital, the Departments of Neurology (Dr Gupta) and Otorhinolaryngology (Dr Mlcoch), Loyola University Medical School, Maywood, Ill, and the Department of Internal Medicine, Chicago Medical School, North Chicago, Ill (Dr Bushnell).

Arch Neurol. 1989;46(6):665-669. doi:10.1001/archneur.1989.00520420085027

• Fourteen patients (10 with left-sided and 4 with right-sided cerebral infarction) were prospectively studied with single-photon emission computed tomography (SPECT) using N-isopropyl-p-(1 123) iodoamphetamine (IMP, SPECTamine) to determine its usefulness in predicting neurologic/language recovery after cerebral infarction. All neuro-SPECT imaging was performed within 30 days after infarction. Detailed assessment of neurologic and/or language recovery (after 3 months) was carried out prospectively in each patient. Patients with smaller volume IMP defects in the region of infarction demonstrated significantly better neurologic and language recovery than patients with large IMP defects. Analysis of the IMP "redistribution" phenomenon failed to demonstrate definitively a relationship with clinical recovery. It was concluded that the volume of the IMP defect can aid in predicting recovery potential after cerebral infarction.

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