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August 1989

Fatigue in Multiple Sclerosis

Author Affiliations

Psychiatry Service Washington Veterans Administration Medical Center 50 Irving St NW Washington, DC 20422

Arch Neurol. 1989;46(8):841-842. doi:10.1001/archneur.1989.00520440021010

To the Editor.  —I read the article "Fatigue in Multiple Sclerosis" by Krupp et al1 in the April 1988 issue of the Archives with interest. In that article, the fatigue frequently experienced by patients with multiple sclerosis (MS) is characterized and proved to be more frequent and severe than the fatigue experienced by normal healthy adults. Interestingly, the fatigue of patients with MS seemed independent of severity of the patients' neurologic deficits, and the severity of the fatigue did not correlate well with depression. I would like to point out some recent developments that might have some role in an improved understanding of MS fatigue. Trotter et al2 have reported finding elevated serum interleukin 2 (IL-2) levels in patients with progressive MS, and Greenberg et al3 have reported finding elevated serum levels of the released form of the IL-2 receptor in patients with MS. Denicoff et al

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