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Article
August 1989

Posterior Cortical Atrophy: A New Clinical Entity, or Alzheimer's Disease?-Reply

Author Affiliations

Neurology Department UCLA School of Medicine 710 Westwood Plaza Los Angeles, CA 90024

Arch Neurol. 1989;46(8):844. doi:10.1001/archneur.1989.00520440024015
Abstract

In Reply.  —Feher, Mahurin, Inbody, and Pirozzolo are correct in their statement that the evidence presented in our article1 is insufficient to support the existence of a new clinical entity called posterior cortical atrophy, but their major arguments are not acceptable. Most of their objections are based on the inability of the neuropsychological tests to demonstrate findings in these patients that could not be found in Alzheimer's disease. Unfortunately, current neuropsychological tests, even when administered in a carefully planned, nonstandard manner, are not reliable in the separation of Alzheimer's disease from a number of other causes of dementia.2Many of the findings in these patients were unlike those present in Alzheimer's disease. The dramatic difference in the verbal and performance scores on the Wechsler Adult Intelligence Scale seen in these patients is not standard for Alzheimer's disease. When this observation is coupled with the early, severe disturbance of high-level visual

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