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September 1989

Seasonal Variation of Multiple Sclerosis Exacerbations in North Dakota

Author Affiliations

From the Department of Neurology, University of North Dakota School of Medicine (Dr Goodkin), and the Department of Statistics, North Dakota State University (Dr Hertsgaard), Fargo. Dr Goodkin is now with The Cleveland (Ohio) Clinic Foundation, Mellen Center for Multiple Sclerosis Treatment and Research.

Arch Neurol. 1989;46(9):1015-1018. doi:10.1001/archneur.1989.00520450085025

• A prospective study of the relationship between exacerbations and season in 336 patients with clinically definite multiple sclerosis showed a significant monthly variation as well as a seasonal pattern of exacerbations. The data obtained are compared with earlier studies that have used varying methodologies. The results continue to support the hypothesis that undefined environmental factors influence the course of multiple sclerosis.