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October 1989

Chronic Manganese Intoxication

Author Affiliations

From the Departments of Neurology, Chang Gung Medical College Hospital (Drs Huang, Chu, and Lu) and National Taiwan University Hospital (Dr Wang), School of Technology, Kaohsiung Medical College (Ms Tsai), and Institute of Nuclear Science, National Tsing-Hua University (Mr Tzeng), Taipei, Taiwan, Republic of China; and the Department of Medicine, Division of Neurology, University of British Columbia, Vancouver (Drs Wolters and Calne).

Arch Neurol. 1989;46(10):1104-1106. doi:10.1001/archneur.1989.00520460090018

• We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa.

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