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November 1989

Primary Lateral Sclerosis

Author Affiliations

Department of Neurology Albert Einstein College of Medicine 1300 Morris Park Ave Bronx, NY 10461

Arch Neurol. 1989;46(11):1166-1167. doi:10.1001/archneur.1989.00520470016012

To the Editor.  —In their article, "Primary Lateral Sclerosis: A Clinical Diagnosis Reemerges,"1 Younger et al cite our article on the use of trimodal evoked potentials in the diagnosis of multiple sclerosis.2 Their statement that our study was "restricted to cases of clinically definite MS" is in error. In fact, of the 26 patients we studied, 23 did not have sufficient findings to permit the diagnosis of multiple sclerosis to be made solely on a clinical basis, and these patients were classified as having possible or suspected multiple sclerosis.The point of our article was to demonstrate the sensitivity and utility of evoked potentials in establishing the presence of clinically silent lesions in patients whose physical examination does not support the diagnosis of clinically definite multiple sclerosis.