To the Editor.
—The Archives recently published two excellent articles1,2 stressing the significance of dementia in patients with multiple sclerosis. In the last 3 years, at the Rush Alzheimer's Disease Center, Chicago, Ill, we have seen three older patients referred to us because of suspected Alzheimer's disease. These three patients (aged 65, 66, and 67 years) all had histories of progressive dementia. In one, mild forgetfulness had been present for as long as 20 years. Two patients had a previous diagnosis of multiple sclerosis, but their general neurologic disability had been mild and had remained stable over many years. Because of this, it was not thought likely by the referring physician that multiple sclerosis could be the cause of the dementia. In the third patient, a diagnosis of multiple sclerosis had never been made. All three patients had abnormalities on physical examination that were consistent with multiple sclerosis (eg
Fox JH, Bernard B, Gilley D, Stebbins GT, Wilson RS, Huckman MS. Multiple Sclerosis: An Unexpected Cause of Senile Dementia. Arch Neurol. 1989;46(12):1269. doi:10.1001/archneur.1989.00520480011004
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.