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Article
December 1989

Cerebral Cavernous Malformations

Author Affiliations

Division of Neurological Surgery Barrow Neurological Institute 350 W Thomas Rd Phoenix, AZ 85013

Arch Neurol. 1989;46(12):1273. doi:10.1001/archneur.1989.00520480015011
Abstract

To the Editor.  —In the February 1989 issue of the Archives, Allard et al1 described several members of a family who had multiple lesions noted on magnetic resonance imaging that were termed arteriovenous malformations. These lesions, however, have the characteristic magnetic resonance imaging appearance of cavernous malformations (angiomas), another type of cerebral vascular malformation.2Cerebral cavernous malformations are masses of abnormally dilated vascular spaces with no intervening brain parenchyma.3,4 These lesions, once regarded as rare, are being diagnosed with increasing frequency with magnetic resonance imaging. In the past, cavernous malformations have often been diagnosed as thrombosed arteriovenous malformations.5 There is a sporadic and a familial form of cerebral cavernous malformation.4 The sporadic form accounts for approximately 50% of cases and is typically associated with a single lesion.4 The familial form of the disorder is common in Mexican-American families, is inherited as an autosomal dominant

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