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Article
January 1990

Plasmapheresis in a Pregnant Patient With Multiple Sclerosis

Author Affiliations

Department of Neurology Medical College of Wisconsin Milwaukee, WI 53226

Arch Neurol. 1990;47(1):11-12. doi:10.1001/archneur.1990.00530010017007
Abstract

To the Editor.  —Plasmapheresis combined with immunosuppressive drug therapy is of proven benefit in both acute and chronic progressive multiple sclerosis.1,2 We present our experience with plasmapheresis alone in a pregnant patient with multiple sclerosis with high-risk obstetric profile and severely progressive multiple sclerosis.

Report of a Case.  —A 28-year-old patient with a clinically definite diagnosis of multiple sclerosis had a 2-month history of progressive neurological deterioration. She was 9 weeks pregnant, confined to a wheel-chair, and unable to stand or transfer independently; unable to feed herself because of weakness; incontinent of bowel and bladder; and experienced diplopia when tired. The previous two pregnancies had resulted in stillbirths.Immunosuppressive drug therapy for her multiple sclerosis was considered to be a relative contraindication because of its adverse effect on the fetus and also given her high-risk obstetric history. Therefore, intensive plasmapheresis (five treatments in 10 days) was begun with significant

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