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Article
January 1990

Carnitine Palmityltransferase Deficiency and Fixed Muscle Weakness-Reply

Author Affiliations

Department of Rheumatology and Immunology Brigham and Women's Hospital 75 Francis St Boston, MA 02115

Arch Neurol. 1990;47(1):13. doi:10.1001/archneur.1990.00530010019011
Abstract

In Reply.  —I would like to thank Nelson and Davis for their bringing to our attention a recently published article regarding low carnitine palmityltransferase enzyme activity and proximal muscle weakness.1 In that case, the muscle biopsy specimen showed ragged red fibers and paracrystalline inclusions by electron microscopy. In both patients in our article,2 ragged red fibers were not seen on light microscopy, and electron microscopy studies did not show paracrystalline inclusions in the mitochondria.

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