To the Editor.
—Acute pandysautonomia is a syndrome characterized by various symptoms of acute paralysis of the sympathetic and parasympathetic functions, apparently without other clinical or neurological abnormalities.1,2 Recovery is partial or complete after several months. The site of the lesion of acute pandysautonomia has generally been assumed to be located in the postganglionic fibers of both sympathetic and parasympathetic neurons.1-3 However, it was suggested that, in the second case of Okada et al3 and in the case of Watanabe et al,4 lesions were present in the preganglionic or central nervous system, because of poor vascular responses to subcutaneous or intravenous injection of sympathomimetic amines and no pupillary response to a low concentration of cocaine or epinephrine instillation in the eyes. Electroencephalographic abnormalities were described by Andersen et al,5 Harik et al,6 and Neville and Sladen.7 Hopkins et al8 described some temporal
Okada F, Shintomi Y. The Central Sites of the Autonomic Nervous System May Also Be Disturbed in Some Cases With Acute Pandysautonomia. Arch Neurol. 1990;47(2):127–128. doi:10.1001/archneur.1990.00530020021008
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: