• Peripheral neuropathy associated with α1-antitrypsin deficiency is an uncommon condition. Several recent studies have investigated the possible roles of serum proteinase inhibitors in inflammatory neuropathies, such as multiple sclerosis, Landry-Guillain-Barré syndrome, and various chronic inflammatory demyelinating peripheral neuropathies. We present a case in which α1-antitrypsin deficiency (proteinase inhibitor ZZ phenotype) was diagnosed in a young white man with clinical signs and symptoms of peripheral neuropathy and a history of Landry-Guillain-Barré syndrome. We wish to emphasize the importance of serum protein electrophoresis in the diagnostic workup of patients presenting with the clinical manifestations of peripheral neuropathy.
Frederick WG, Enriquez R, Bookbinder MJ. Peripheral Neuropathy Associated With α1-Antitrypsin Deficiency. Arch Neurol. 1990;47(2):233–235. doi:10.1001/archneur.1990.00530020147031
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