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March 1990

Magnetic Resonance Imaging and Clinical Correlates of Intellectual Impairment in Myotonic Dystrophy-Reply

Author Affiliations

Columbus, Ohio

Arch Neurol. 1990;47(3):254. doi:10.1001/archneur.1990.00530030017006

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In Reply.  —We have read with interest the comments of Brumback regarding the influence of tricyclics on behavioral features of myotonic dystrophy. In fact, due to their possible influence on cognitive and depressive features of the disease, none of the patients who were in our study had been taking antidepressants for at least 6 months prior to the time of examination. The exact role of tricyclics in the treatment of myotonic dystrophy is at present uncertain due to the lack of doubleblind studies, but the preliminary data provided by Brumback and associates certainly suggest that such studies may be worthwhile.

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