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March 1990

Serum Interleukin 2 and Soluble Interleukin 2 Receptor in Patients With Multiple Sclerosis Who Are Experiencing Severe Fatigue

Author Affiliations

Department of Neurology Mellen Center for Multiple Sclerosis Treatment and Research
Department of Immunopathology Cleveland Clinic Foundation Cleveland, OH 44106

Arch Neurol. 1990;47(3):254-255. doi:10.1001/archneur.1990.00530030018008

To the Editor.  —Elevated levels of serum interleukin 2 (Il-2) and soluble interleukin 2 receptor (sIl-2r) have been related to active sarcoidosis.1 It has been suggested that this may reflect disease activity, since Il-2 is secreted by activated T lymphocytes and sIl-2r is shed by activated T lymphocytes during the course of a cell-mediated immune response.2 Boutin and associates3 reported that serum levels of sIl-2r were markedly increased in patients with acute encephalitis, suggesting that the intrathecal immune response was reflected by elevated systemic levels of sIl-2r. Elevated systemic levels of Il-2 and sIl-2r have been reported in patients with multiple sclerosis,4-6 stimulating questions about whether these parameters can be used to measure disease activity, to estimate prognosis, or to explain certain clinical manifestations of the disease.We measured Il-2 and sIl-2r in eight patients with multiple sclerosis who each experienced persisting and debilitating fatigue. All

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