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April 1990

The Morphological Substrate of Cerebral Asymmetry: the Problem of Its Measurement

Author Affiliations

Institute of Anatomy Medical University Lübeck Ratzeburger Allee 160 D-2400 Lübeck, West Germany

Arch Neurol. 1990;47(4):379. doi:10.1001/archneur.1990.00530040019005

To the Editor.  —Albanese et al1 analyzed the asymmetry of weight and cortical surface in the anterior speech region of the inferior frontal gyrus and its different parts. They found a left predominance in the posterior portion, which is concerned with language. Their results showed an excellent correlation between weight and surface values. The weight and surface ratio was the same for the portions related to language and different for the remainder of the inferior frontal gyrus. This was the most recent of a series of articles2-11 trying to find a morphological substrate for functional asymmetries. All these articles have in common the fact that they used unsuitable methods to achieve their goal.The most reliable method to detect structural differences between brain regions is quantitative morphology or morphometry. These evaluation procedures have been applied to prove or disprove structural differences between the left and right hemisphere,12

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