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April 1990

Tubular Aggregates in Skeletal Muscle Associated With Neoplastic Disease

Author Affiliations

Department of Neurology West Virginia University Health Sciences Center Morgantown, WV 26506

Arch Neurol. 1990;47(4):382-383. doi:10.1001/archneur.1990.00530040022013

To the Editor.  —Tubular aggregates in skeletal muscle have been described in an increasing variety of disorders, including periodic paralysis; muscular dystrophies; inflammatory myopathies; chronic alcoholism; familial neuromuscular disease characterized by myalgia; and a variety of drug exposures, including anticonvulsants.1-7 We report the observation of tubular aggregates in skeletal muscle from a patient with neoplastic disease and suggest that a pathogenetic relationship may exist between the development of tubular aggregates and the disturbance in calcium metabolism and regulation that frequently occurs in neoplastic disease.

Report of a Case.  —A 73-year-old man with no prior history of myalgias, muscle cramps, or muscle weakness presented with a 3-month history of orthostatic hypotension with occasional syncope, night sweats, and a 7-kg weight loss. His blood pressure was 120/60 mm Hg supine, with a pulse rate of 90 beats per minute. On standing, his blood pressure dropped to 70/42 mm Hg, with a

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