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July 1990

Magnetic Resonance Imaging in Parkinson's Disease

Author Affiliations

From the Departments of Neurology (Drs Huber and Paulson) and Radiology (Dr Chakeres and Mr Khanna), The Ohio State University College of Medicine, Columbus.

Arch Neurol. 1990;47(7):735-737. doi:10.1001/archneur.1990.00530070023006

• Magnetic resonance imaging was utilized to examine changes in the pars compacta associated with Parkinson's disease. We found a reduction in average width of the pars compacta in advanced- but not early-stage patients. Conversely, a significant difference in width (right minus left) was observed in early- but not late-stage patients. Width asymmetry may be a sensitive magnetic resonance imaging indicator for the early detection of Parkinson's disease when there is a predominance of unilateral clinical symptoms.

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