• Magnetic resonance imaging was utilized to examine changes in the pars compacta associated with Parkinson's disease. We found a reduction in average width of the pars compacta in advanced- but not early-stage patients. Conversely, a significant difference in width (right minus left) was observed in early- but not late-stage patients. Width asymmetry may be a sensitive magnetic resonance imaging indicator for the early detection of Parkinson's disease when there is a predominance of unilateral clinical symptoms.
Huber SJ, Chakeres DW, Paulson GW, Khanna R. Magnetic Resonance Imaging in Parkinson's Disease. Arch Neurol. 1990;47(7):735–737. doi:10.1001/archneur.1990.00530070023006
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