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July 1990

Autosomal Dominant Cramping Disease

Author Affiliations

From the Department of Neurology, University of Würzburg, West Germany (Dr Ricker); and the Departments of Neurology and Pediatrics, University of Rochester (NY) School of Medicine and Dentistry (Dr Moxley).

Arch Neurol. 1990;47(7):810-812. doi:10.1001/archneur.1990.00530070108019

• A family was studied in which four generations (16 of 41 members) suffered from painful recurrent muscle cramping. A clear pattern of autosomal dominant inheritance was noted. The cramping first developed during adolescence or early adulthood. Electromyographic analysis indicated a neurogenic origin. The cramps seemed to be due to dysfunction of the motor neurons. The mechanisms underlying this alteration are unclear and require further investigation.

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