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August 1990

Electrophysiologic Comparisons Between Two Groups of Patients With Alzheimer's Disease

Author Affiliations

From the Departments of Psychiatry and Neurology, Massachusetts General Hospital (Dr Albert), and the Department of Neurology, Children's Medical Center (Drs Duffy and McAnulty), Harvard Medical School, Boston, Mass.

Arch Neurol. 1990;47(8):857-863. doi:10.1001/archneur.1990.00530080039008

• Two groups of patients with Alzheimer's disease were compared using brain electrical activity mapping. The patients were selected on the basis of their cognitive history. The initial symptom of disease of the patients in group 1 was a significant and profound memory deficit, whereas the patients in group 2 initially presented with a gradually progressive spatial impairment. Fourteen topographic features distinguished the groups. Eleven of the 14 features pertained to electrical activity differences in parietal regions, and 9 were bilateral. These features were highly correlated with cognitive measures that are also useful in distinguishing the groups.

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