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October 1990

No Evidence for Human T-cell Leukemia Virus Type I or Human T-cell Leukemia Virus Type II Infection in Patients With Multiple Sclerosis

Author Affiliations

From the Second Department of Medicine, Semmelweis University (Drs Perl, Pazmany, Baraczka, and Szabo), MTA-IKI (Dr Nagy), and Department of Neurology, Weil Emil Hospital (Dr Baraczka), Budapest, Hungary; and the Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY (Drs Perl and Isaacs).

Arch Neurol. 1990;47(10):1061-1063. doi:10.1001/archneur.1990.00530100023007

• The involvement of human T-cell leukemia viruses (HTLVs) in the pathogenesis of 18 Hungarian patients with multiple sclerosis was investigated. No antibody to HTLVs could be detected in any of the patients. Furthermore, using polymerase chain reaction under highly sensitive conditions, neither HTLV-I DNA nor HTLV-II DNA could be noted in peripheral blood lymphocytes of the patients. Our data do not support a causal association of HTLV-I or HTLV-II with multiple sclerosis.