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November 1990

Quantitative Imaging: Neuroreceptors, Neurotransmitters, and Enzymes

Author Affiliations

Rochester, NY

Arch Neurol. 1990;47(11):1166. doi:10.1001/archneur.1990.00530110018006

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A comprehensive overview of the application of positron emission tomography (PET) for the localization and quantification of neurotransmitters, their receptors, and enzymes will be attained by a reader of this book. The first two chapters describe the concept of neurotransmitter receptors and their localization by both in vitro and in vivo techniques. As an introduction to the use of PET, receptor autoradiography is briefly discussed. Positron emission tomography has many advantages over receptor autoradiography, the greatest benefit being that it is a noninvasive technique. After an overview of neurotransmitters and their receptors in disease, the basics of PET are described, starting with the radiochemistry of tracers for neurotransmitter receptors and the description of the physics and instrumentation of PET. These chapters on the principles of PET and the radioactive tracers used in PET are particularly useful to the reader who is not completely familiar with the basis of PET. Individuals

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