• A retrovirus was isolated from a T-cell line that was established from lymphocytes in the cerebrospinal fluid of a patient with human T-cell leukemia virus type I-associated myelopathy (HAM), and its genome was sequenced. The nucleotide sequence of the 3' half of the total genome was identical in 99.5% of the nucleotides to that of the prototype human T-cell leukemia virus type I that was derived from a patient with adult T-cell leukemia. These results indicate that the same retrovirus human T-cell leukemia virus type I is associated with both a neurological disease, HAM, and a lymphoproliferative disease, adult T-cell leukemia.
Shirabe S, Nakamura T, Tsujihata M, Nagataki S, Seiki M, Yoshida M. Retrovirus From Human T-Cell Leukemia Virus Type I-Associated Myelopathy Is the Same Strain as a Prototype Human T-Cell Leukemia Virus Type I. Arch Neurol. 1990;47(11):1258–1260. doi:10.1001/archneur.1990.00530110120029
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