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November 1990

Retrovirus From Human T-Cell Leukemia Virus Type I-Associated Myelopathy Is the Same Strain as a Prototype Human T-Cell Leukemia Virus Type I

Author Affiliations

From the Department of Viral Oncology, Cancer Institute, Tokyo, Japan (Drs Shirabe, Seiki, and Yoshida), and the Department of First Internal Medicine (Dr Tsujihata) and The School of Allied Medical Sciences (Drs Shirabe, Nakamura, and Nagataki), Nagasaki (Japan) University.

Arch Neurol. 1990;47(11):1258-1260. doi:10.1001/archneur.1990.00530110120029

• A retrovirus was isolated from a T-cell line that was established from lymphocytes in the cerebrospinal fluid of a patient with human T-cell leukemia virus type I-associated myelopathy (HAM), and its genome was sequenced. The nucleotide sequence of the 3' half of the total genome was identical in 99.5% of the nucleotides to that of the prototype human T-cell leukemia virus type I that was derived from a patient with adult T-cell leukemia. These results indicate that the same retrovirus human T-cell leukemia virus type I is associated with both a neurological disease, HAM, and a lymphoproliferative disease, adult T-cell leukemia.

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