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March 1991

Seizure Disorders in Down Syndrome

Author Affiliations

From the Departments of Pediatrics (Dr Pueschel) and Neurology (Drs Louis and McKnight), Rhode Island Hospital, Providence.

Arch Neurol. 1991;48(3):318-320. doi:10.1001/archneur.1991.00530150088024

• The prevalence, onset, and type of seizure disorders, as well as seizure control, were studied in a large cohort of 405 individuals with Down syndrome (age range, 6 months to 45 years). The evaluation of a questionnaire completed by the subjects' parents and of the patients' medical records indicated that 33 (8.1%) of 405 persons with Down syndrome had seizure disorder. With regard to the onset of seizures, a bimodal distribution was noted: 40% of patients began having seizures before the age of 1 year, and another 40% started with seizure activity in the third decade of life. In the younger age group, primarily infantile spasms and tonic-clonic seizures with myoclonus were observed, and the older patients often had partial simplex or partial complex seizures as well as tonic-clonic seizures.

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