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—We appreciate the useful comments provided by Doraiswamy and associates. While we tried to make our report as methodologically sound as possible, they correctly point out that we did not fully evaluate the potential effects of age. The age (mean ± SD) for the mild Parkinson's disease group (61.4 ± 8.7), the moderate/severe Parkinson's disease group (66.1 ± 8.0), and the normal control subjects (68.4 ± 4.0) produced a difference among groups that just failed to reach statistical significance, F(2,51) = 2.99, P <.06. However, the relatively young age of the mild Parkinson's disease group does warrant an examination of the potential effects of age on our results. We performed an analysis of covariance, with age as the covariate, on both the average width and width difference on the first echo images. There was a significant difference among the groups for width average, F(3,50) = 3.64, P <.02,
Huber SJ. Magnetic Resonance Evaluation of the Midbrain in Parkinson's Disease-Reply. Arch Neurol. 1991;48(4):360. doi:10.1001/archneur.1991.00530160020008
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