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May 1991

Amyotrophic Lateral Sclerosis. Concepts in Pathogenesis and Etiology

Author Affiliations

Rochester, NY

Arch Neurol. 1991;48(5):465. doi:10.1001/archneur.1991.00530170025006

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This book is a collection of 15 papers presented in 1987. Contributors include the editor, Dr Arthur Hudson, who is the founder of the Amyotrophic Lateral Sclerosis (ALS) Society of Canada, and Drs Antel, Calne, Dalakas, Eisen, Gajdusek, Hirano, Kurland, and others who have been important, long-time students of ALS and other neurodegenerative disorders. The interest of the presentations ranges broadly. This is a sampling of observations put forth in some of the reports: "Use of cultured human fetal spinal cord neurons currently represents the most promising model system in which to explore the cause of ALS." "Sera from a proportion of patients with ALS and other denervating diseases produce a... decrease [sic] of motoneuron death during embryonic development." "Classic ALS... apparently results in impaired metabolism of gangliosides, which leads to rapid death of motor neurons." "Understanding of the molecular basis of the retrovirus-induced motor neuron disease in mice... we

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