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May 1991

Germ Cell Tumors Masquerading as Central Nervous System Sarcoidosis

Author Affiliations

From the Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Md (Drs Peeples and Stern); the Division of Neurology (Dr Stern) and the Department of Pathology (Dr Jiji), Sinai Hospital of Baltimore (Md); and the Department of Neurosurgery, Medical College of Virginia, Richmond (Dr K. Singh Sahni).

Arch Neurol. 1991;48(5):554-556. doi:10.1001/archneur.1991.00530170118031

• The diagnosis of central nervous system sarcoidosis is uncertain without typical multisystem involvement. We describe two patients with isolated central nervous system mass lesions whose biopsy results were consistent with sarcoidosis. After a progressive clinical course, they were found to have diencephalic germinomas. Germ cell tumors, in particular, should be considered in the differential diagnosis of central nervous system sarcoidosis as they are potentially treatable, occur in intracranial locations favored by sarcoidosis mass lesions, and may be surrounded by granulomatous inflammation that can be mistaken for the noncaseating granulomas of sarcoidosis.

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