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September 1991

Delayed Varicella Vasculopathy

Author Affiliations

Division of Neurology Brigham and Women's Hospital 75 Francis St Boston, MA 02115

Arch Neurol. 1991;48(9):900. doi:10.1001/archneur.1991.00530210026013

To the Editor.  —I read with great interest the article by Caekebeke et al.1 They carefully document a case of a 5-year-old boy who suffered from an acute hemiparesis 3 and 9 months after a chickenpox infection.However, I disagree with their contention that this association had not been previously reported. Earlier, Holmes and I2 described a 3½-year-old boy who developed a hemiparesis 1 month after a varicella infection. Eda et al3 in 1983 had already reported four similar cases, and then Kamholz and Tremblay4 documented another.The ages of the six patients2-4 ranged from 1 to 6 years of age, and the time between onset of varicella and onset of hemiparesis varied from 1 to 3 months. Cranial imaging studies revealed infarcts involving the basal ganglia and internal capsule in all six cases. Caekebeke and coworkers' patient1 differs slightly because he had two