[Skip to Navigation]
September 1991

Clinical and Morphometric Analysis of the Hypoplastic Corpus Callosum

Author Affiliations

From the Division of Genetics, Endocrinology, and Metabolism, Department of Pediatrics (Dr Schaefer), and Department of Radiology (Dr Wilson), Oklahoma University College of Medicine, Oklahoma City; Department of Neurology (Dr Bodensteiner), West Virginia University College of Medicine, Morgantown; and Department of Zoology (Dr Thompson), University of Oklahoma, Norman. Dr Schaefer is now with the University of Nebraska Medical Center, Omaha.

Arch Neurol. 1991;48(9):933-936. doi:10.1001/archneur.1991.00530210059024

• A total of 307 children were evaluated over a 3-year period in our neurogenetics clinic. Review of their medical records demonstrated 26 patients with diagnoses of anomalies of the corpus callosum. Morphometric analysis was performed on those 23 patients qualitatively assessed as having a hypoplastic (small, but morphologically intact) corpus callosum. Morphometric data were compared with clinical correlates for each patient. From these data, we conclude that the hypoplastic corpus callosum is not a normal variant of development but rather an indicator of a more fundamental abnormality of cerebral development.

Add or change institution