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September 1991

Lower Extremity Motor Evoked Potentials in Multiple Sclerosis

Author Affiliations

From the Department of Neurology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pa. Dr Jones is now in private practice, Scranton, Pa.

Arch Neurol. 1991;48(9):944-948. doi:10.1001/archneur.1991.00530210070026

• Transcranial magnetic stimulation was performed on 25 patients with definite multiple sclerosis. Motor evoked potentials were recorded from the anterior tibial muscle. Central motor conduction time was calculated using the equation (F + M-1)/2 by stimulation of the common peroneal nerve. Motor evoked potentials were capable of detecting subclinical pyramidal tract lesions in multiple sclerosis. In patients with multiple sclerosis, the incidence of abnormality of motor and somatosensory evoked potentials was similar. Central motor conduction time was correlated with overall and pyramidal tract subscores on the Kurtzke Disability Status Scale and the Scripps Neurological Rating Scale. Central motor conduction time abnormalities correlated best with the presence of a Babinski's sign but also correlated significantly with weakness and hyperreflexia.

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