[Skip to Navigation]
November 1991

Concerning the Distribution of Cerebral Muscarinic Acetylcholine Receptors in Alzheimer's Disease-Reply

Author Affiliations

Clinical Brain Disorders Branch National Institute of Mental Health Neuroscience Center at St Elizabeths 2700 Martin Luther King Jr Ave SE Washington, DC 20032

Arch Neurol. 1991;48(11):1118. doi:10.1001/archneur.1991.00530230025012

In Reply.  —In his letter, Zeeberg questions whether the radioiodinated 3-quinuclidinyl-4-iodobenzilate (IQNB) single photon emission computed tomographic (SPECT) images in normal subjects and in patients with dementia described in our article1 reflect primarily muscarinic receptor binding or regional cerebral blood flow (rCBF). We discussed this issue extensively in our article and spoke directly and repeatedly to the concern raised in this letter. Nevertheless, the author of this letter ignores most of our discussion and most of the in vivo data about IQNB, choosing instead to challenge a "straw man" of his own construction. He focuses on our observation regarding the cerebellum and uses this to build his case for an rCBF phenomenon. The cerebellum observation, as clearly discussed in our article, served only to demonstrate that the SPECT images at prolonged times after IQNB administration were distinctly different from, and in marked contrast to, rCBF images, and they indicated

Add or change institution