• Recent clinical and research reports suggest that the cerebellum may contribute to the modulation of higher order behavior. This article presents a critical review of both earlier and more current clinical observations that raise this possibility, as well as a review of the salient laboratory data that appear to support this contention. It also summarizes the relevant anatomic work concerning the contributions to the cortico-pontocerebellar pathways from the higher order cerebral association areas, which have been implicated as partial anatomic substrates for this putative cerebellar role in higher function. Finally, it provides a framework for the understanding of this correlation, concludes with suggestions for future areas of investigation, and recommends that patients with cerebellar lesions be studied from a neurobehavioral point of view.
Schmahmann JD. An Emerging Concept: The Cerebellar Contribution to Higher Function. Arch Neurol. 1991;48(11):1178–1187. doi:10.1001/archneur.1991.00530230086029
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: