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December 1991

The Role of Brain Single Photon Emission Computed Tomography in the Diagnosis of Primary Progressive Aphasia

Author Affiliations

From the Departments of Neurology (Dr McDaniel); Psychiatry (Dr McDaniel); Orthopaedics, Division of Rehabilitation Medicine (Dr Wagner); Radiology, Division of Nuclear Medicine (Dr Greenspan), University of Rochester (NY) School of Medicine and Dentistry.

Arch Neurol. 1991;48(12):1257-1260. doi:10.1001/archneur.1991.00530240061021

• We present two cases of primary progressive aphasia studied with neuropsychologic measures, computed tomography or magnetic resonance imaging, and single-photon emission computed tomography with technetium Tc 99m-labeled hexamethyl-propyleneamine oxime. Clinical and neuropsychologic observations revealed a marked, progressive loss of language functions over time with relative preservation of nonlanguage cognitive functions in both patients. The brain single-photon emission computed tomographic scan revealed marked left frontal and minimal left temporal and parietal hypoperfusion in case 1 and marked left posterior frontal and minimal left temporal hypoperfusion in case 2. The value of brain single-photon emission computed tomography in distinguishing primary progressive aphasia from Alzheimer's disease is described.

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