• We treated a 62-year-old woman who developed a dramatic change in personality and behavior following a discrete left-sided medial thalamic infarction involving the dorsomedial nucleus. Neuropsychological testing demonstrated severe impairment of complex executive behaviors that are usually associated with frontal lobe function. Electroencephalography and single-photon emission computed tomography strongly implicated dysfunction of the ipsilateral frontal lobe. This case further supports a functional and physiologic thalamofrontal linkage as part of a broader cerebral network modulating complex human behavior.
Sandson TA, Daffner KR, Carvalho PA, Mesulam M. Frontal Lobe Dysfunction Following Infarction of the Left-Sided Medial Thalamus. Arch Neurol. 1991;48(12):1300–1303. doi:10.1001/archneur.1991.00530240106031
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